Chilton Medical Center - ATLANTIC HEALTH SYSTEM
Decrease (-) Restore Default Increase (+)  font size
PrintEmail
Search Health Information   

Endocrine glands
Endocrine glands


Hypercalcemia

Definition:

Hypercalcemia is too much calcium in the blood.



Causes, incidence, and risk factors:

Calcium is important to many body functions, including:

  • Bone formation
  • Hormone release
  • Muscle contraction
  • Nerve and brain function

Parathyroid hormone (PTH) and vitamin D help manage calcium balance in the body. PTH is made by the parathyroid glands -- four small glands located in the neck behind the thyroid gland. Vitamin D is obtained when the skin is exposed to sunlight, and from dietary sources such as:

  • Egg yolks
  • Fish
  • Fortified cereals
  • Fortified dairy products

Primary hyperparathyroidism is the most common cause of hypercalcemia. It is due to excess PTH release by the parathyroid glands. This excess occurs due to an enlargement of one or more of the parathyroid glands, or a growth (usually not cancer) on one of the glands.

Other medical conditions can also cause hypercalcemia:

  • Adrenal gland failure
  • An inherited condition that affects the body's ability to regulate calcium (familial hypocalciuric hypercalcemia)
  • Being bedbound (or not being able to move) for a long period of time
  • Calcium excess in the diet (called milk-alkali syndrome, usually due to at least 2,000 milligrams of calcium per day)
  • Hyperthyroidism
  • Kidney failure
  • Medications such as lithium and thiazide diuretics (water pills)
  • Some cancerous tumors (for example, lung cancers, breast cancer)
  • Vitamin D excess (hypervitaminosis D ) from diet or inflammatory diseases

Hypercalcemia affects less than 1 percent of the population. The ability to measure blood calcium since the 1960s has improved detection. Today, the condition is diagnosed at an early stage so most patients with hypercalcemia have no symptoms.

Women over age 50 are most likely to have hypercalcemia, usually due to primary hyperparathyroidism.



Symptoms:

Abdominal symptoms:

Kidney symptoms:

Muscle symptoms:

Psychological symptoms:

Skeletal symptoms:



Signs and tests:

Treatment:

Treatment is aimed at the cause of hypercalcemia whenever possible. In people with primary hyperparathyroidism (PHPT), surgery may be needed to remove the abnormal parathyroid gland and cure the hypercalcemia.

However, if the hypercalcemia is mild, your health care provider will offer you the option of monitoring your condition closely over time.

Severe hypercalcemia that causes symptoms and requires a hospital stay is treated with the following:

  • Calcitonin
  • Dialysis
  • Diuretic medication, such as furosemide
  • Drugs that stop bone breakdown and absorption by the body, such as pamidronate or etidronate (bisphosphonates)
  • Fluids through a vein (intravenous fluids)
  • Glucocorticoids (steroids)


Support Groups:



Expectations (prognosis):

How well you do depends on the cause of hypercalcemia. Patients with mild hyperparathyroidism or hypercalcemia with a treatable cause do well and usually do not have complications.

Patients with hypercalcemia due to conditions such as cancer or granulomatous disease may not do well, but this is usually due to the disease itself, rather than the hypercalcemia.



Complications:

Gastrointestinal

Kidney

Psychological

  • Depression
  • Difficulty concentrating or thinking

Skeletal

These complications of long-term hypercalcemia are uncommon today.



Calling your health care provider:

Contact your physician or health care provider if you have:

  • Family history of hypercalcemia
  • Family history of hyperparathyroidism
  • Symptoms of hypercalcemia


Prevention:

Most causes of hypercalcemia cannot be prevented. Women over age 50 should see their health care provider regularly and have their blood calcium level checked if they have symptoms of hypercalcemia.

You can avoid hypercalcemia from calcium and vitamin D supplements by contacting your health care provider for advice about the dose if you are taking supplements without a prescription.



References:

Bringhurst R, Demay MB, Kronenberg HM. Hormones and disorders of mineral metabolism. In: Williams Textbook of Endocrinology. 11th ed. Philadelphia, Pa: Saunders Elsevier; 2008:chap 27.

Wysolmerski JJ, Insogna KL. The parathyroid glands, hypercalcemia, and hypocalcemia. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 266.




Review Date: 3/22/2012
Reviewed By: Shehzad Topiwala, MD, Chief Consultant Endocrinologist, Premier Medical Associates, The Villages, FL. Review Provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M. Health Solutions, Ebix, Inc.

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
adam.com


Morristown Medical Center
100 Madison Avenue
Morristown, NJ 07960
973-971-5000

Overlook Medical Center
99 Beauvoir Avenue
Summit, NJ 07901
908-522-2000

Newton Medical Center
175 High Street
Newton, NJ 07860
973-383-2121

Chilton Medical Center
97 West Parkway
Pompton Plains, NJ 07444
973-831-5000

Goryeb Children's Hospital
100 Madison Avenue
Morristown, NJ 07960
973-971-5000

© 2014 Chilton Medical Center, 97 West Parkway, Pompton Plains, New Jersey 1-973-831-5000