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Red blood cells, sickle cell
Red blood cells, sickle cell


Red blood cells, multiple sickle cells
Red blood cells, multiple sickle cells


Red blood cells, sickle cells
Red blood cells, sickle cells


Red blood cells, sickle and pappenheimer
Red blood cells, sickle and pappenheimer


Blood cells
Blood cells


Hemolytic anemia

Definition:

Anemia is a condition in which the body does not have enough healthy red blood cells. Red blood cells provide oxygen to body tissues.

Normally, red blood cells last for about 120 days in the body. In hemolytic anemia, red blood cells in the blood are destroyed earlier than normal.



Alternative Names:

Anemia - hemolytic



Causes:

Hemolytic anemia occurs when the bone marrow is unable to replace the red blood cells that are being destroyed.

Immune hemolytic anemia occurs when the immune system mistakenly sees your own red blood cells as foreign substances. Antibodies then develop against the red blood cells. These antibodies attack the red blood cells and cause them to break down too early.

Red blood cells may be destroyed due to:

  • Genetic defects within the red cells (such as sickle cell anemia, thalassemia, and G6PD deficiency)
  • Exposure to certain chemicals, drugs, and toxins
  • Infections

Other causes are:

  • Blood clots in small blood vessels
  • Transfusion of blood from a donor with a blood type that does not match yours


Symptoms:

You may not have symptoms if the anemia is mild. If the problem develops slowly, the first symptoms may be:

  • Feeling grumpy
  • Feeling weak or tired more often than usual, or with exercise
  • Headaches
  • Problems concentrating or thinking

If the anemia gets worse, symptoms may include:

  • Blue color to the whites of the eyes
  • Brittle nails
  • Light-headedness when you stand up
  • Pale skin color
  • Shortness of breath
  • Sore tongue


Exams and Tests:

A test called a complete blood count (CBC) can help diagnose anemia and offer some hints to the type and cause of the problem. Important parts of the CBC include red blood cell count (RBC), hemoglobin, and hematocrit (HCT).

These tests can identify the type of hemolytic anemia:



Treatment:

Treatment depends on the type and cause of the hemolytic anemia:

  • In emergencies, a blood transfusion may be needed.
  • For an overactive immune system, drugs that suppress the immune system may be used.
  • When blood cells are being destroyed at a fast pace, the body may need extra folic acid and iron supplements to replace what is being lost.

In rare cases, surgery is needed to take out the spleen. This is because the spleen acts as a filter that removes abnormal cells from the blood.



Outlook (Prognosis):

Outcome depends on the type and cause of hemolytic anemia. Severe anemia can make heart disease, lung disease, or cerebrovascular disease worse.



When to Contact a Medical Professional:

Call your health care provider if you develop symptoms of hemolytic anemia.



References:

Jager U, Lechner K. Autoimmune hemolytic anemia. In: Hoffman R, Benz EJ Jr, Silberstein LE, et al., eds. Hematology: Basic Principles and Practice. 6th ed. Philadelphia, Pa: Elsevier Saunders; 2012:chap 44.

Price EA, Schrier SS. Extrinsic nonimmune hemolytic anemias. In: Hoffman R, Benz EJ Jr, Silberstein LE, et al., eds. Hematology: Basic Principles and Practice. 6th ed. Philadelphia, Pa: Elsevier Saunders; 2012:chap 45.




Review Date: 2/24/2014
Reviewed By: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
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Morristown Medical Center

100 Madison Avenue
Morristown, NJ 07960
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Overlook Medical Center

99 Beauvoir Avenue
Summit, NJ 07901
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Newton Medical Center

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Newton, NJ 07860
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Pompton Plains, NJ 07444
973-831-5000

Goryeb Children's Hospital

100 Madison Avenue
Morristown, NJ 07960
973-971-5000

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