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Central nervous system
Central nervous system


Secondary parkinsonism

Definition:

Secondary parkinsonism is similar to Parkinson disease , but the symptoms are caused by certain medicines, a different nervous system disorder, or another illness.

Parkinsonism refers to any condition that involves the types of movement problems seen in Parkinson disease. These problems include tremors, slow movement, and stiffness of the arms and legs.



Alternative Names:

Parkinsonism - secondary; Atypical Parkinson disease



Causes:

Secondary parkinsonism may be caused by health problems, including:

Other causes of secondary parkinsonism include:

  • Brain damage caused by anesthesia drugs (such as during surgery)
  • Carbon monoxide poisoning
  • Certain medicines used to treat mental disorders or nausea
  • Mercury poisoning and other chemical poisonings
  • Overdoses of narcotics
  • MPTP (a contaminant in some street drugs)

There have been rare cases of secondary parkinsonism among IV drug users who injected a substance called MPTP, which can be produced when making a form of heroin.



Symptoms:

Common symptoms include:

  • Decrease in facial expressions
  • Difficulty starting and controlling movement
  • Loss or weakness of movement (paralysis)
  • Soft voice
  • Stiffness of the trunk, arms, or legs
  • Tremor

Confusion and memory loss may be likely in secondary parkinsonism. This is because many diseases that cause secondary parkinsonism also lead to dementia .



Exams and Tests:

The health care provider will perform a physical exam and ask questions about the person's medical history and symptoms. Be aware that the symptoms may be hard to assess, particularly in the elderly.

Examination may show:

  • Difficulty starting or stopping voluntary movements
  • Tense muscles
  • Problems with posture
  • Slow, shuffling walk
  • Tremors (shaking)

Reflexes are usually normal.

Tests may be ordered to confirm or rule out other problems that can cause similar symptoms.



Treatment:

If the condition is caused by a medicine, the provider may recommend changing or stopping the medicine.

Treating underlying conditions, such as stroke or infections, can reduce symptoms or prevent the condition from getting worse.

If symptoms make it hard to do everyday activities, the provider may recommend medicine. Medicines used to treat this condition can cause severe side effects. It is important to see the provider for check-ups. Secondary parkinsonism tends to be less responsive to medical therapy than Parkinson disease.



Outlook (Prognosis):

Unlike Parkinson disease, some types of secondary parkinsonism may stabilize or even improve if the underlying cause is treated. Brain problems, such as Lewy body disease, are not reversible.



Possible Complications:

This condition may lead to these problems:

  • Difficulty doing daily activities
  • Difficulty swallowing (eating)
  • Disability (varying degrees)
  • Injuries from falls
  • Side effects of medicines used to treat the condition

Side effects from loss of strength (debilitation):



When to Contact a Medical Professional:

Call the provider if:

  • Symptoms of secondary parkinsonism develop, come back, or get worse
  • New symptoms appear, including confusion and movements that cannot be controlled
  • You are unable to care for the person at home after treatment starts


Prevention:

Treating conditions that cause secondary parkinsonism may decrease the risk.

People taking medicines that can cause secondary parkinsonism should be carefully monitored by the provider to prevent the condition from developing.



References:

Jankovic J. Movement disorders. In: Daroff RB, Fenichel GM, Jankovic J, Mazziotta JC, eds. Bradley's Neurology in Clinical Practice. 6th ed. Philadelphia, PA: Elsevier Saunders; 2012:chap 71.

Lang AE. Parkinsonism. In: Goldman L, Schafer AI. Goldman's Cecil Medicine. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 409.




Review Date: 8/13/2015
Reviewed By: Joseph V. Campellone, MD, Division of Neurology, Cooper University Hospital, Camden, NJ. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.

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Morristown Medical Center

100 Madison Avenue
Morristown, NJ 07960
973-971-5000

Overlook Medical Center

99 Beauvoir Avenue
Summit, NJ 07901
908-522-2000

Newton Medical Center

175 High Street
Newton, NJ 07860
973-383-2121

Chilton Medical Center

97 West Parkway
Pompton Plains, NJ 07444
973-831-5000

Hackettstown Medical Center

651 Willow Grove Street
Hackettstown, NJ 07840
908-852-5100

Goryeb Children's Hospital

100 Madison Avenue
Morristown, NJ 07960
973-971-5000

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