Chilton Medical Center - ATLANTIC HEALTH SYSTEM
Decrease (-) Restore Default Increase (+)  font size
PrintEmail
Search Health Information   

Blood test
Blood test


Immunofixation - blood

Definition:

Serum immunofixation is a lab test to identify proteins called immunoglobulins in blood. Too much of the same immunoglobulin is usually due to different types of blood cancer. Immunoglobulins are antibodies that help your body fight infection.



Alternative Names:

Serum immunofixation



How the Test is Performed:

A blood sample is needed.



How to Prepare for the Test:

There is no special preparation for this test.



How the Test will Feel:

When the needle is inserted to draw blood, some people feel moderate pain. Others feel only a prick or stinging. Afterward, there may be some throbbing or a slight bruise. This soon goes away.



Why the Test is Performed:

This test is most often used to check the levels of certain antibodies associated with multiple myeloma and Waldenstrom macroglobulinemia .Those antibodies include IgG , IgM , IgA , lambda light chain forms, and kappa light chain forms.

Immunofixation has also been used to study changes in protein structure (for example, glucose-6-phosphate dehydrogenase ), and in the genetic typing of alpha-1 antitrypsin .



Normal Results:

A normal result means no monoclonal (meaning an excess of one specific type of) immunglobulins are seen in the blood sample.



What Abnormal Results Mean:

An abnormal result may be due to:

  • Amyloidosis
  • Leukemia
  • Lymphoma
  • Monoclonal gammopathy of unknown significance (MGUS)
  • Multiple myeloma
  • Waldenstrom macroglobulinemia
  • Other cancers


Risks:

There is very little risk involved with having your blood taken. Veins and arteries vary in size from one patient to another and from one side of the body to the other. Taking blood from some people may be more difficult than from others.

Other risks associated with having blood drawn are slight but may include:

  • Excessive bleeding
  • Fainting or feeling light-headed
  • Hematoma (blood accumulating under the skin)
  • Infection (a slight risk any time the skin is broken)


References:

McPherson RA, Massey HD. Laboratory evaluation of immunoglobulin function and humoral immunity. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 22nd ed. Philadelphia, PA: Elsevier Saunders; 2011:chap 46.




Review Date: 5/29/2014
Reviewed By: Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital, Boston, MA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
adam.com


Morristown Medical Center
100 Madison Avenue
Morristown, NJ 07960
973-971-5000

Overlook Medical Center
99 Beauvoir Avenue
Summit, NJ 07901
908-522-2000

Newton Medical Center
175 High Street
Newton, NJ 07860
973-383-2121

Chilton Medical Center
97 West Parkway
Pompton Plains, NJ 07444
973-831-5000

Goryeb Children's Hospital
100 Madison Avenue
Morristown, NJ 07960
973-971-5000

Atlantic Medical Group
1-800-247-9580

Morristown Medical Center

100 Madison Avenue
Morristown, NJ 07960
973-971-5000

Overlook Medical Center

99 Beauvoir Avenue
Summit, NJ 07901
908-522-2000

Newton Medical Center

175 High Street
Newton, NJ 07860
973-383-2121

Chilton Medical Center

97 West Parkway
Pompton Plains, NJ 07444
973-831-5000

Goryeb Children's Hospital

100 Madison Avenue
Morristown, NJ 07960
973-971-5000

Affiliated Providers

Atlantic Medical Group

More than 600 community-based health care providers.
1-800-247-9580

© 2015 Chilton Medical Center, 97 West Parkway, Pompton Plains, New Jersey 1-973-831-5000