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Factor V assay

Definition:

The factor V assay is a blood test to measure the activity of factor V. This is a substances involved in blood clotting (coagulation).



How the Test is Performed:

A sample of blood will be taken from your vein.



How to Prepare for the Test:

No special steps are needed to prepare for this test.



How the Test will Feel:

You may feel slight pain or a sting when the needle is inserted to draw blood. You may feel some throbbing afterward.



Why the Test is Performed:

This test is used to find the cause of too much bleeding (decreased blood clotting).



Normal Results:

The value is normally 50 - 200% of the laboratory control or reference value.

Normal value ranges may vary slightly among different laboratories. Talk to your doctor about the meaning of your specific test results.

The examples above show the common measurements for results for these tests. Some laboratories use different measurements or may test different specimens.



What Abnormal Results Mean:

Decreased factor V activity may be related to:



Risks:

Veins and arteries vary in size so it may be harder to take a blood sample from one person than another.

Other slight risks associated with having blood drawn may include:

  • Excessive bleeding
  • Fainting or feeling light-headed
  • Hematoma (blood accumulating under the skin)
  • Infection (a slight risk any time the skin is broken)

This test is most often performed on people who have bleeding problems. The risk of excessive bleeding is slightly greater than for people without bleeding problems.



Considerations:

When you bleed, the body starts a series of reactions that help the blood clot. This is called the coagulation cascade. The process involves special proteins called coagulation factors (factor V is a coagulation factor).

Each factor's reaction triggers the next reaction. The final product of the coagulation cascade is the blood clot . Blood clots may not form normally if any one of the clotting factors is abnormally low.



References:

Ragni MV. Hemorrhagic Disorders: Coagulation Factor Deficiencies. In: Goldman L, Schafer AI, eds. Goldman's Cecil Medicine. 24th ed. Philadelphia, PA: Saunders Elsevier; 2011:chap 177.

Gailani D, Neff AT. Rare Coagulation Deficiencies. In: Hoffman R, Benz EJ Jr, Silberstein LE, Heslop HE, Weitz JI, eds. Hematology: Basic Principles and Practice. 6th ed. Philadelphia, PA: Saunders Elsevier; 2012:chap 139.




Review Date: 3/3/2013
Reviewed By: Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital. Also reviewed by A.D.A.M. Health Solutions, Ebix, Inc., Editorial Team: David Zieve, MD, MHA, Bethanne Black, Stephanie Slon, and Nissi Wang.

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Morristown Medical Center

100 Madison Avenue
Morristown, NJ 07960
973-971-5000

Overlook Medical Center

99 Beauvoir Avenue
Summit, NJ 07901
908-522-2000

Newton Medical Center

175 High Street
Newton, NJ 07860
973-383-2121

Chilton Medical Center

97 West Parkway
Pompton Plains, NJ 07444
973-831-5000

Goryeb Children's Hospital

100 Madison Avenue
Morristown, NJ 07960
973-971-5000

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